Printed edition of "Kompass", 3_2008. IGHH. International Society of Homeopathy and Homotoxicology.
Current international research indicates that vascular and metabolic syndrome (MBC) It is multifactorial phenomenon. Early signs of AIM are:
- accumulation of abdominal fat
- fatty liver cells
- dyslipidemia: low concentrations of high-density cholesterol, elevated triglycerides
- systemic inflammation
- disturbances in insulin secretion and processing of glucose.
According to the table of the six phases Reckeweg, these early signs of the MBC are manifestations of excretion phase (allocation), and inflammation of the deposit. At this stage MFR patient still left of the biological barrier, and can prevent further development through such MBC preventive measures such as weight reduction and increased physical activity. Therefore, it is crucial to recognize the signs of AIM, and to correlate them with the six phase table to avoid progressive vicariation.
Long before there comes a complete atrophy of the beta cells of the pancreas (impregnation phase), it is the negative impact caused by the temporary quantitative and qualitative defects on the island cells in the pancreas. As a result of violations of the first phase insulin secretion, when he released a powerful and fast development of this hormone in the second phase takes place in a compensatory increase in volume. At the same time the body eventually reaches its limit due to lack carboxypeptidase N. Instead, insulin is secreted in increased quantity of proinsulin.
"Fire" inflammation in MBC "lights" and "supported by" a multitude of factors. A crucial role is played by visceral adipose tissue. Fat cells, the size and number of which increases in overweight, antilipolytic become resistant to the action of insulin. This leads to an excess of free fatty acids. Visceral adipose tissue is not only fat depots, but also extremely active secretory organ. It is among other things produces adipokines, hormones, inhibitor-1 plasminogen activator, which plays an important role in the development of cardiovascular diseases, and various inflammatory mediators. Important factors in this phase of inflammation are interleukin-6 (IL-6) and tumor necrosis factor (TNF). IL-6 has predicative value when a type II diabetes. TNF inhibits the kinase activity of the receptor to insulin, resulting in increased insulin resistance of cells.
Impregnation phase due homotoxins, formed during abnormal metabolism in the phases of excretion and inflammations. It starts a cascade of homotoxins, leading eventually to the late complications of diabetes and metabolic syndrome, vascular. The results of the latest molecular studies show that giperklikemiya (latently present already in the excretion phase) induces four mechanisms that are crucial for the further course of pathological processes in metabolism.
Sorbitol accumulates predominantly in neuronal cells and plays an important role in the onset of diabetic polyneuropathy.
For the first time open the French chemist Maillard glycation end products (advancedglycationendproducts, AGEs: proteins and lipids react with reducing sugars, enzyme not glikoliziruyutsya not oxidized), by changing the activity of the corresponding proteins have a negative impact on the final bodies. The end products of glycosylation (CNG) attack the extracellular matrix proteins and alter it. Because CPG bound receptor RAGEi stimulate it, this leads to an increased oxidative stress and in the activation of the transcription factor NF-kB. As a result, there are local and systemic inflammatory responses and reduction in levels of nitric oxide (NO).
Numerous studies leading role of protein kinase C in the occurrence of late complications of diabetes has been proven. A large number of activated at MBC angiotensin II receptor, endothelin I and norepinephrine actually hyperglycemia, reactive oxygen species, the passage of the polyol metabolic paths and CNG activate protein kinase C, resulting in an enhanced expression of inflammatory mediators.
Intermittent fluctuations in blood sugar and fatty acids (which began in the phases of excretion, and inflammation) and increasing insulin resistance causes increased generation of oxygen free radicals (TFR) and the imbalance between the protective antioxidant mechanisms and TFR.
By the impregnation phase should also include pro-inflammatory and edematous altered matrix. The matrix acts as a filter in metabolism. All substances or information from the capillaries of the autonomic nervous system must overcome the transit portion of the extracellular matrix. By impregnation of homotoxins transported in a matrix broken.
Homotoxins vascular and metabolic syndrome are: glucose, sorbitol, protein kinase C, inflammatory mediators, CPG, free oxygen radicals and free fatty acids.
In this phase, the pathological exchange process progresses so that stop functioning pancreatic beta cells. In addition, the homotoxins by this time already damaged endothelium and called endothelial dysfunction. It is the result of inflammatory processes in the endothelium, increased release of oxygen free radicals and inflammatory mediators as well as reducing the content of nitrogen oxide. Endothelial dysfunction is characterized by infiltration of monocytes are divided into macrophages and foam cells in the vessel wall. CD4-positive lymphocytes found in the vessel wall to antigens, such as oxidized low-density lipoproteins, and are converted from TN0 type TH1 type cells, which promotes continuation of the pro-inflammatory process.
At this stage, due to overload homotoxins occur complications such as violations of the macro- and microcirculation, retinopathy, neuropathy, nephropathy. Defeats authorities have not decompensated.
Violations of the macro- and microcirculation and polinevropaticheskaya cause dysregulation of the occurrence of the disease. Locally destroyed metabolism and stops the supply of oxygen. The result can be organ damage such as loss of vision, and heart attacks. With an advanced diabetic nephropathy is no longer a sufficient filtration capacity. There are secondary homotoxins, such as urea, uric acid and creatinine. These secondary homotoxins are the reason that patients become dependent on dialysis.
Phase dedifferentsirovaniya characterize as myocardial infarction, apoplectic stroke, and amputation.
With phase dedifferentsirovaniya correlated and identified in numerous international studies cumulated cancer patients with advanced MBC. This demonstrates published in "JAMA" (Journal of the American Medical Association), a prospective cohort study of 1.2 million Koreans, as well as a study published in "Gastroenterology" magazine, which proved a positive correlation between patients with type II diabetes receiving insulin treatment, and frequency occurrence of colon cancer.
In practice, it is particularly useful to analyze, at what stage the patient has to be able to start a course of antihomotoxic treatment.
Dr. Ulrike Kyme, Bonn